Alcohol dependence is a chronic illness the prognosis of which may be improved with drug therapy. Psychosocial therapies without combination with drug therapy provide minor to moderate effect in mild or moderate alcohol dependence . Supervised medication with naltrexone or disulfiram , when combined with psychosocial therapies will improve therapy outcomes. With acamprosate , respectively, the outcomes may be improved. The best results have been achieved by combining pharmacological agents with therapy aimed at controlling alcohol use and preventing relapses and with family and network therapies.