Violence against women has become a sensitive topic in the last few decades. Policies contrasting violence against women, research, awareness-raising and training projects are lacking. Several attempts were made to find a shared framework at international-regional level, given the uncertainty and diversity at the level of individual national jurisdictions. The Istanbul Convention, with its innovations and the ability to tackle the issue in the light of modernization and globalization, is, in this sense, one of the most useful tools for proposing uniform regulation on this issue. The comparative analysis with the different realities, not only national, but above all cultural, social, highlights the normative diversity, as well as the frame of the effective application of the convention itself.