G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders

Ram K. Mishra (Curatore)

Glen B. Baker (Curatore)

Humana Press Inc., 1997

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

• Curatore: Ram K. Mishra, Glen B. Baker
• Editore: Humana Press Inc.
• Collana: Neuromethods
• Anno: 1997
• Rilegatura: Hardback
• Pagine: 433 p.
• Dimensioni: 235 x 155 mm
• EAN: 9780896034907

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