Non-Myeloablative Allogeneic Transplantation

Asad Bashey (Curatore)

Edward D. Ball (Curatore)

Springer-Verlag New York Inc., 2012

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

• Curatore: Asad Bashey, Edward D. Ball
• Editore: Springer-Verlag New York Inc.
• Collana: Cancer Treatment and Research
• Anno: 2012
• Rilegatura: Paperback / softback
• Pagine: 216 p.
• Dimensioni: 235 x 155 mm
• EAN: 9781461353041

Testo in English