Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles

di Hyung Yoon (Autore)

Springer Nature Switzerland AG, 2021

This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, andhighlights its synthetic utility.   Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and p-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.

• Autore: Hyung Yoon
• Editore: Springer Nature Switzerland AG
• Collana: Springer Theses
• Anno: 2021
• Rilegatura: Paperback / softback
• Pagine: 212 p.
• Dimensioni: 235 x 155 mm
• EAN: 9783030540791

Testo in English