Supercool - The Physics, Mathematics, and Engineering of Cryogenesis

di Kai Voss (Autore)

Kai Voss, 2026

Master the Physics and Engineering of Macro-Scale Cryogenesis For decades, cryobiology focused successfully on microscopic cell suspensions, leaving macro-scale organ preservation constrained by the destructive limits of ice crystal formation, thermal shock, and vascular collapse. Supercool: The Physics, Mathematics, and Engineering of Cryogenesis bridges the gap between low-temperature physics and advanced biomedical engineering, providing a comprehensive roadmap for achieving stable, ice-free biological stasis. Written for biosystems engineers, researchers, and students, this authoritative textbook deconstructs the entire engineering lifecycle of advanced bio-preservation. Explore how modern engineering transforms biological stasis from a theoretical challenge into a scalable industrial reality. Key Technical Focus Areas: Deep Sub-Zero Thermodynamics: Master classical nucleation theory, phase equilibria, transient heat conduction via Fourier's law, and latent heat of fusion dynamics. Vascular Perfusion Physics: Navigate complex fractal microvascular networks, non-Newtonian CPA viscosity profiles, and convective-diffusive transport coupling. Vitrification & Glass Transition Engineering: Optimize critical cooling rates ($q$), manage glass transition kinetics ($T_g$), and leverage high-pressure phase shifts. Fracture Mechanics & Stress Relief: Mitigate thermal stress, differential contraction mismatches, and micro-cracking using macromolecular polymers and isothermal annealing. Nanoparticle-Assisted Rapid Warming: Defeat the re-warming crisis and prevent devitrification using superparamagnetic iron oxide nanoparticles (SPIONs) and alternating magnetic fields (AMF). Ischemic & Metabolic Preservation: Combat ATP depletion, oxidative stress cascades, and mitochondrial permeability transition pore (mPTP) failure. Post-Thaw Recovery & Biofabrication: Execute automated microfluidic stepwise CPA dilution curves, restore endothelial nitric oxide signaling, and integrate detergent-decellularized ECM scaffolds. Whether you are designing next-generation organ preservation hardware, optimizing cryogenic biobanking logistics, or exploring the future of regenerative medicine, Supercool provides the rigorous quantitative framework required to conquer biological time and space.

• Autore: Kai Voss
• Anno edizione: 2026
• Editore: Kai Voss
• Formato: EPUB2 con DRMFREE
• Lingua: Inglese
• Compatibilità: Tutti i dispositivi (eccetto Kindle)
• Layout: Reflowable
• EAN: 9798235452787