Prostaglandin E1: New Aspects on Pharmacology, Metabolism and Clinical Efficacy

Curt Diehm (Curatore)

Helmut Sinzinger (Curatore)

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 1992

Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour­ able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi­ 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously.

• Curatore: Curt Diehm, Helmut Sinzinger
• Editore: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
• Anno: 1992
• Rilegatura: Paperback / softback
• Pagine: 117 p.
• Dimensioni: 235 x 155 mm
• EAN: 9783540545248

Testo in English