Bioisosteres in Medicinal Chemistry

Nathan Brown (Curatore)

Wiley-VCH Verlag GmbH, 2012

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

• Curatore: Nathan Brown
• Editore: Wiley-VCH Verlag GmbH
• Collana: Methods & Principles in Medicinal Chemistry
• Anno: 2012
• Rilegatura: Hardback
• Pagine: 256 p.
• Dimensioni: 246 x 174 mm
• Peso: 631 gr.
• EAN: 9783527330157

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