Biology of Cancer, The

di Ray Arters (Autore)

Jayjay Ham LLC, 2025

This audiobook is narrated by a digital voice. Cancer represents one of the most complex and formidable challenges in modern biology and medicine, characterized by the fundamental breakdown of normal cellular control mechanisms that maintain tissue homeostasis and organismal integrity. At its essence, cancer is a disease of cellular behavior where individual cells escape the regulatory constraints that normally govern their growth, division, and death, leading to uncontrolled proliferation and the potential to invade distant tissues. This transformation from normal to malignant cell behavior involves the accumulation of genetic and epigenetic alterations that progressively disrupt the molecular machinery responsible for maintaining cellular order and cooperation within multicellular organisms. The hallmarks of cancer, as originally articulated by Douglas Hanahan and Robert Weinberg, provide a conceptual framework for understanding how normal cells become transformed into cancer cells through the acquisition of specific capabilities that enable malignant behavior. These hallmarks include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. More recent updates to this framework have included reprogramming energy metabolism, evading immune destruction, genome instability and mutation, and tumor-promoting inflammation as additional enabling characteristics that support cancer development and progression.

• Autore: Ray Arters
• Durata in (hh:mm:ss): 01:01:14
• Anno edizione: 2025
• Editore: Jayjay Ham LLC
• EAN: 9798318122712

Testo in en