Formulating Poorly Water Soluble Drugs

Robert O. Williams III (Curatore)

Alan B. Watts (Curatore)

Springer International Publishing AG, 2018

The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop

• Curatore: Robert O. Williams III, Alan B. Watts
• Editore: Springer International Publishing AG
• Collana: AAPS Advances in the Pharmaceutical Sciences Series
• Anno: 2018
• Rilegatura: Paperback / softback
• Pagine: 779 p.
• Dimensioni: 235 x 155 mm
• EAN: 9783319826189

Testo in English