Strides made in the last four decades in the field of engineering and medicine have now established mechanical support for heart failure patients as a viable and effective strategy. This technology has seen an improvement in its application since the 1980s. However, most of the current available books related to outdated technology. There is an imminent need for a comprehensive reference work that details the latest developments in this technology. This text covers all clinical, design, technical, and relevant engineering aspects regarding mechanical circulatory devices.