The Origins of Depression: Current Concepts and Approaches: Report of the Dahlem Workshop on The Origins of Depression: Current Concepts and Approaches Berlin 1982, Oct.31 – Nov. 5

J. Angst (Curatore)

A. Carlsson (Curatore)

Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 2011

3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de­ pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu­ mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex­ plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco­ logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields.

• Curatore: J. Angst, A. Carlsson
• Editore: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
• Collana: Life Sciences Research Report
• Anno: 2011
• Rilegatura: Paperback / softback
• Pagine: 474 p.
• Dimensioni: 229 x 152 mm
• EAN: 9783642691317

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