Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

Curatore: Li Di, Edward H. Kerns
Anno: 2015
Rilegatura: Hardback
Pagine: 600 p.
Testo in English
Dimensioni: 245 x 171 mm
Peso: 950 gr.
  • EAN: 9781118788356
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Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant - and most challenging - areas of drugdiscovery. - Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects - Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies - Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes - Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) - Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market