GERD: A New Understanding of Pathology, Pathophysiology, and Treatment

Parakrama T. Chandrasoma

Anno: 2017
Rilegatura: Hardback
Pagine: 652 p.
Testo in English
Dimensioni: 276 x 216 mm
Peso: 2020 gr.
  • EAN: 9780128098554
pagabile con 18App pagabile con Carta del Docente

Articolo acquistabile con 18App e Carta del Docente

€ 113,53

€ 123,40

Risparmi € 9,87 (8%)

Venduto e spedito da IBS

114 punti Premium

Disponibile in 5 gg lavorativi

Quantità:

Altri venditori

Mostra tutti (2 offerte da 123,40 €)

Descrizione
GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.